Laccaic acid , luonnontuote, jossa on oxodikarboxyylihaapo substituutio , E904 Shellack

 https://pubchem.ncbi.nlm.nih.gov/compound/Laccaic-acid-A

 

PubChem CID	5491415
Structure	Find Similar Structures
Molecular Formula	C26H19NO12
Synonyms	LACCAIC ACID A 15979-35-8 CHEMBL2037378 CHEBI:90186 7-[5-(2-acetamidoethyl)-2-hydroxyphenyl]-3,5,6,8-tetrahydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid More...
Molecular Weight	537.4
Dates	Modify 2023-04-01 Create 2005-08-09
Laccaic acid A is a tetrahydroxyanthraquinone that is that is 3,5,6,8-tetrahydroxy-9,10-anthraquinone substituted by two carboxy groups at positions 1 and 2 as well as a 5-(2-acetamidoethyl)-2-hydroxyphenyl group at position 7. The major component of LAC dye together with laccaic acids B, C and D It has a role as a dye, an animal metabolite and an EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor. It is a tetrahydroxyanthraquinone, an acetamide, a polyphenol and an oxo dicarboxylic acid. !0 Biological Test Results New Window 10.1BioAssay Results New Window 34 items View More Rows & Details Sort by Activity Activity Value, µM Activity Type Target Name BioAssay Name BioAssay AID Substance SID Active 0.39 IC50 GPR35 - G protein-coupled receptor 35 (human) Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins 663960 160689780 Active 0.39 EC50 GPR35 - G protein-coupled receptor 35 (human) Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay 663955 160689780 Active 0.65 IC50 DNMT3A - DNA methyltransferase 3 alpha (human) DNA Methylation Assay from Article 10.1074/jbc.M113.480517: "Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1." 1802375 160863872 Active 0.65 IC50 DNMT1 - DNA methyltransferase 1 (human) DNA Methylation Assay from Article 10.1074/jbc.M113.480517: "Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1." 1802375 160863872 Active 0.65 IC50 CPG DNA methylase (Spiroplasma monobiae) DNA Methylation Assay from Article 10.1074/jbc.M113.480517: "Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1." 1802375 160863872 1 ...